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KMID : 0358419950380122371
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Korean Journal of Obstetrics and Gynecology
1995 Volume.38 No. 12 p.2371 ~ p.2377
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Detection of Human Papilloma Virus DNA and Expression of c-myc and Ha-ras Oncogens in Uterine Cervical Carcinomas
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Abstract
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The aim of the study was to investigate the role of human papillomavirus(HPV) and c-myc and Ha-ras oncogenes in carcinoma in situ and invasive cervical carcinoma.
The presence of high-risk HPV(16/18, 31/33/35) DNA and expression of c-myc and c-Ha-ras oncogenes were studied in paraffin embedded specimens obtained from 312 patients by using in situ hypbridization and immunohistochemisty.
Of 116 patients with carcinoma in situ, c-myc and Ha-ras expression was found in 14(37.8%) and 17(45.9%) patients with HPV DNA compared to 16(20.3%) and 19(24.4%) without HPV DNA(P<0.05). Of 196 patients with invasive squamous cell carcinoma,
c-myc
and
Ha-ras expression was found in 21(27.6%) and 30(39.5%) patients with HPV DNA, 36(30%) and 48(40%) without HPV. Ha-ras oncogene was detected in 24.4% of patients with carcinoma in situ while in 40% of invasive squamous cell carcinoma without HPV
DNA(p<0.05).
Our results suggest that c-myc and Ha-ras oncogenes' expression and HPV infection could play a role in the carcinogenesis of invasive squamous cell carcinoma of the cervix.
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KEYWORD
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